50 Years of Research and Discovery in Chronic Kidney Disease and Mineral & Bone Disorder: The Central Role of Phosphate
نویسندگان
چکیده
INTRODUCTION A Phosphate Centric Forum, supported by Genzyme Corporation, was held on 24–25 June, 2010 at the Sheraton West Park Hotel, Munich, Germany, in which 25 medical and scientifi c experts in the fi eld of chronic kidney disease-related mineral and bone disorder (CKD-MBD) met to present and discuss the central role of phosphate in the development of CKD-MBD, on which research has now celebrated its 50th anniversary. Phosphate plays a central role in the pathophysiology of CKD-MBD and the progression of CKD and contributes to the disproportionate cardiovascular risk faced by patients with CKD. Adaptation of nephrons attempting to preserve phosphate homeostasis requires endocrine tradeoff s that fuel adverse events of hyperphosphatemia in CKD—secondary hyperparathyroidism, calcium and vitamin 50 Years of Research and Discovery in Chronic Kidney Disease and Mineral & Bone Disorder: The Central Role of Phosphate
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